Impact of Hemophilia A

Hemophilia A can significantly impair a patient’s quality of life. Patients with severe hemophilia A experience frequent intra-articular and intramuscular bleeds. If not receiving prophylactic treatment, these patients can expect to have an average of 20 to 30 spontaneous or trauma-related bleeding episodes a year.1 

Recurrent joint bleeding can result in chronic synovitis, defined as inflammation within a joint, or chronic arthropathy, which is deterioration of joint cartilage and bone. Over time, these conditions may cause physical impairment, negative psychosocial consequences, and disability.2

 

References: 1. Dargaud Y, Negrier C. Haemophilia therapies. Expert Opin Biol Ther. 2007;651-663. 2. DiMichele D. Hemophilia 1996: New approach to an old disease. Pediatr Clin North Am. 1996;43:709-736.