Inhibitor Formation

In some people treated with factor VIII replacement therapy, the body's immune system mistakes the therapy as a threat. In response, the immune system makes antibodies, called inhibitors, that attack the factor VIII. Inhibitors are a very serious problem because they prevent, or inhibit, factor VIII replacement therapy from controlling bleeding.1

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Reference: 1. Mannucci PM, Abshire T, Dimichele D, et al. Inhibitor development, immune tolerance and prophylaxis in haemophilia A—the need for an evidence-based approach. Haemophilia. 2006;12:429–434.