Hemophilia A Treatment Options

The mainstay of treatment is FVIII replacement. FVIII can be supplied as either plasma-derived or recombinant.1 In addition to on-demand treatment with FVIII for bleeding episodes, prophylactic therapy can be given at regular intervals to prevent life-threatening hemorrhages and musculo-articular bleeding events.1

Patients with inhibitors can be treated with high-dose FVIII replacement; undergo immune tolerance induction, or ITI, to tolerize the immune system to FVIII; and/or use bypass agents, such as prothrombin complex concentrates, or PCCs, to stop a bleeding episode.1

Reference: 1. Dargaud Y, Negrier C. Haemophilia therapies. Expert Opin Biol Ther. 2007;651-663.